The top teams in the 15th Region met Monday night in the East Kentucky Expo Center with a trip to the 15th Region Championship on the line.
Pikeville took control early opening on a 9-0 run.
Floyd Central would try to come back, but couldn't quite overcome the early deficit. The Lady Jaguars cut the Lady Panthers lead to 9 in the third quarter.
The Lady Panthers were too much ultimately winning 61-46. Pikeville was led by 18 points from Kristen Cole-Williamson, 15 of those in the first half.
Floyd Central's loss was the first to a Regional opponent this year.
Pikeville will meet Johnson Central Tuesday Night at 7 p.m.